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Heparin and Nitrolingual

Determining the interaction of Heparin and Nitrolingual and the possibility of their joint administration.

Check result:

Heparin <> Nitrolingual

Relevance: 14.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using heparin together with nitroglycerin may decrease the effects of heparin. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. You may need a dose adjustment in addition to special tests to safely use both medications. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

Professional:

MONITOR: The concurrent administration of heparin and intravenous nitroglycerin may lead to a decreased anticoagulant effect. Data are conflicting and the mechanism is unknown.

MANAGEMENT: If these agents are coadministered or if the nitroglycerin is discontinued, consider close evaluation of the coagulation status of the patient and titrate the heparin dose as needed.

References

Barnette RE, Brister NW "Heparin nitroglycerin interaction." Anesthesiology 71 (1989): 991
Raschke R, Guidry J, Laufer N, Peirce J "Nitroglycerin-induced heparin resistance." Am Heart J 121 (1991): 1849-50
Bushe C, Wales E "A possible interaction between heparin and intravenous nitroglycerin." Am J Cardiol 68 (1991): 290
Habbab MA, Haft JI "Intravenous nitroglycerin and heparin resistance." Ann Intern Med 105 (1986): 305
Nottestad SY, Mascette AM "Nitroglycerin-induced heparin resistance - absence of interaction at clinically relevant doses." Mil Med 159 (1994): 569-71
Gonzalez ER, Jones HD, Graham S, Elswick RK "Assessment of the drug interaction between intravenous nitroglycerin and heparin." Ann Pharmacother 26 (1992): 1512-4

Heparin

Generic Name: heparin

Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush

Synonyms: Heparin Injection

What is Heparin?

Nitrolingual

Generic Name: nitroglycerin

Brand name: Gonitro, Nitrolingual, NitroMist, Nitrostat, Nitro-Time, Gonitro, Minitran, Nitro TD Patch-A, Nitro-Dur, Nitro-Bid, Nitrol Appli-Kit, Rectiv

Synonyms: n.a.

What is Nitrolingual?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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