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Heparin and Dextrose and Penicillin G Sodium Injection

Determining the interaction of Heparin and Dextrose and Penicillin G Sodium Injection and the possibility of their joint administration.

Check result:

Heparin and Dextrose <> Penicillin G Sodium Injection

Relevance: 20.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Case reports have suggested that intravenous penicillins may intensify the effect of heparin by inhibition of platelet aggregation; however, causality has not been clearly determined. Patients should be monitored for bleeding problems. Protamine sulfate may be useful for clinically important bleeding.

References

Wisloff F, Larsen JP, Dahle A, Lie M, Godal HC "Effect of prophylactic high-dose treatment with ampicillin and cloxacillin on bleeding time and bleeding in patients undergoing elective vascular surgery." Scand J Haematol 31 (1983): 97-101
Tabernero JM, Corbacho RL, Sanchez S, et al "Effects of carbenicillin on blood coagulation: a study in patients with chronic renal failure." Clin Nephrol 11 (1979): 31-4
Brown CH, Natelson EA, Bradshaw W, Williams TW, Alfrey CP "The hemostatic defect produced by carbenicillin." N Engl J Med 291 (1974): 265-70

Heparin and Dextrose

Generic Name: heparin

Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush

Synonyms: Heparin Injection, Heparin

What is Heparin and Dextrose?

Penicillin G Sodium Injection

Generic Name: penicillin g sodium

Brand name:

Synonyms: Penicillin G sodium, Penicillin G Sodium Injection

What is Penicillin G Sodium Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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