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Heparin and Sodium Chloride and Telavancin

Determining the interaction of Heparin and Sodium Chloride and Telavancin and the possibility of their joint administration.

Check result:
Heparin and Sodium Chloride <> Telavancin
Relevance: 28.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using heparin together with telavancin is not recommended. Telavancin may interfere with tests that are used to monitor the effectiveness of certain blood thinners. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Although telavancin does not interfere with coagulation, it may artificially prolong activated partial thromboplastin time (aPTT) test results for up to 18 hours following its administration. Telavancin binds to the artificial phospholipid surfaces added to common anticoagulation tests, thereby interfering with the ability of the coagulation complexes to assemble on the surface of the phospholipids and promote clotting in vitro.

MANAGEMENT: Concomitant use of telavancin and intravenous unfractionated heparin sodium is considered contraindicated. For patients who require aPTT monitoring while being treated with telavancin, a non-phospholipid dependent coagulation test such as a Factor Xa (chromogenic) assay or an alternative anticoagulant not requiring aPTT monitoring may be considered.

References
  • "Product Information. Vibativ (telavancin)." Theravance Inc, South San Francisco, CA.
Heparin and Sodium Chloride

Generic Name: heparin

Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush

Synonyms: Heparin Injection, Heparin

Telavancin

Generic Name: telavancin

Brand name: Vibativ

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle