Heparin Lock Flush Solution and Kefzol injection
Determining the interaction of Heparin Lock Flush Solution and Kefzol injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Cefazolin has been associated with an increase in prothrombin time and episodes of bleeding. These effects may potentiate the effects of heparin. Usually, no special management is necessary, but the patient should be monitored for bleeding if cefazolin and heparin must be given together. Vitamin K has been successfully used to treat cephalosporin-induced coagulopathies.
- Khaleeli M, Giorgio AJ "Defective platelet function after cephalosporin administration." Blood 48 (1976): 791-2
- Angaran DM, Dias VC, Arom KV, et al "The comparative influence of prophylactic antibiotics on the prothrombin response to warfarin in the postoperative prosthetic cardiac valve patient." Ann Surg 206 (1987): 155-61
- Lerner PI, Lubin A "Coagulopathy with cefazolin in uremia." N Engl J Med 290 (1974): 1324
Generic Name: heparin
Brand name: Hep-Pak, Heparin Lock flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage, HepFlush
Synonyms: Heparin Injection, Heparin
Generic Name: cefazolin
Brand name: Ancef, Kefzol
Synonyms: Kefzol (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Heparin Lock Flush Solution-Kelnor
- Heparin Lock Flush Solution-Kelnor 1/35
- Heparin Lock Flush Solution-Kelnor 1/35-28
- Heparin Lock Flush Solution-Kelnor 1/50
- Heparin Lock Flush Solution-Kemadrin
- Heparin Lock Flush Solution-Kemstro
- Kefzol injection-Heparin Sodium
- Kefzol injection-Heparin, Concentrate
- Kefzol injection-Hepatamine
- Kefzol injection-Hepatasol Injection
- Kefzol injection-Hepatitis A adult vaccine
- Kefzol injection-Hepatitis A and Hepatitis B Recombinant Vaccine