About us Contacts Drug interactions: 390 212
Drug search by name

Hexalen and Pyridoxine (Vitamin B6) Extended-Release Tablets

Determining the interaction of Hexalen and Pyridoxine (Vitamin B6) Extended-Release Tablets and the possibility of their joint administration.

Check result:
Hexalen <> Pyridoxine (Vitamin B6) Extended-Release Tablets
Relevance: 02.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using pyridoxine together with altretamine. Using these medications together may cause altretamine to be less effective. Contact your doctor if you condition worsens. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Data from a randomized trial of altretamine and cisplatin in ovarian cancer indicated that pyridoxine significantly reduced neurotoxicity but also adversely affected response duration. The mechanism of interaction has not been established.

MANAGEMENT: Until further data are available, it may be advisable to avoid using altretamine with pyridoxine.

References
  • Wiernik PH, Yeap B, Vogl SE, et al "Hexamethylmelamine and low or moderate dose cisplatin with or without pyridoxine for treatment of advanced ovarian carcinoma: a study of the Eastern Cooperative Oncology Group." Cancer Invest 10 (1992): 1-9
  • "Product Information. Hexalen Capsules (altretamine)." US Bioscience, West Conshohoken, PA.
Hexalen

Generic Name: altretamine

Brand name: Hexalen

Synonyms: n.a.

Pyridoxine (Vitamin B6) Extended-Release Tablets

Generic Name: pyridoxine

Brand name: Vitamin B6, Vitelle Nestrex, Pyridoxal 5'-Phosphate

Synonyms: Pyridoxine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.