Hexalen and Silenor

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using doxepin together with altretamine can lower your blood pressure. Low blood pressure can cause dizziness or feeling like you might pass out, especially when getting up from a sitting or lying position. This may be more likely to occur in older adults or those with a debilitating condition. Use caution when getting up from a sitting or lying position, and let your doctor know if you develop these symptoms. You may need a dose adjustment if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration of altretamine with a monoamine oxidase inhibitor (MAOI) or tricyclic antidepressant may result in severe orthostatic hypotension. The mechanism of interaction has not been established. According to one case report, four patients over 60 years of age experienced symptomatic hypotension after 4 to 7 days of concomitant therapy with altretamine and one of the following: amitriptyline, imipramine, or phenelzine. All patients became asymptomatic within 24 to 96 hours after discontinuing the antidepressant. One patient subsequently received and tolerated nortriptyline without clinical symptoms, although a postural drop in systolic blood pressure was observed.

MANAGEMENT: Caution is advised if altretamine must be used with a MAOI or tricyclic antidepressant, particularly in elderly patients. All patients receiving the combination should be advised to avoid rising abruptly from a sitting or lying position and to contact their physician if they experience symptoms of hypotension such as dizziness, lightheadedness, or fainting.

Hexalen

Generic Name: altretamine

Brand name: Hexalen

Synonyms: n.a.

What is Hexalen?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?