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Histex and Vizimpro

Determining the interaction of Histex and Vizimpro and the possibility of their joint administration.

Check result:

Histex <> Vizimpro

Relevance: 24.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Dacomitinib may increase the blood levels and effects of chlorpheniramine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with dacomitinib may increase the plasma concentrations of drugs that are substrates of the CYP450 2D6 isoenzyme. The mechanism is reduced clearance due to inhibition of CYP450 2D6 by dacomitinib. When dextromethorphan, a probe substrate for CYP450 2D6, was coadministered with a single 45 mg dose of dacomitinib, dextromethorphan peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 9.7- and 9.6-fold, respectively. The interaction may be particularly important for sensitive CYP450 2D6 substrates or those that demonstrate a narrow therapeutic index.

MANAGEMENT: Caution is advised if dacomitinib is used in combination with CYP450 2D6 substrates. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever dacomitinib is added to or withdrawn from therapy. Avoid concomitant use with dacomitinib where minimal increases in concentration of the CYP450 2D6 substrate may lead to serious or life-threatening toxicities.

References

"Product Information. Vizimpro (dacomitinib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

Histex

Generic Name: chlorpheniramine / pseudoephedrine

Brand name: Allerest Maximum Strength, Dicel, LoHist-D, SudoGest Sinus & Allergy, Triaminic Cold and Allergy, Clorfed, Histalet, Fedahist, Tanafed, Novafed A, Chlorafed HS. Timecelles, Codimal-LA, Kronofed-A-Jr, Rescon, Rescon JR, Dura-Tap/PD, Fedahist Timecaps, Orlenta, Chlorphedrin SR, Colfed-A, D-Amine-SR, Deconomed SR, Pseudocot-C, Duralex, Rinade-BID, Suphenamine-SR, Isophen-DF, Kronofed-A, ND Clear, Chlordrine SR, Anamine TD, Time-Hist, Chlorafed Timecelles, Brexin LA, Rescon-Ed, Deconamine SR, Pseudochlor, Cophene No. 2, Anaplex, Anamine, Klerist-D, Codimal-LA Half, Fedahist Gyrocaps, Deconamine, Clorfed II, Curaler, Sudafed Plus, Chlorafed, Histafed LA, Chlor Trimeton Allergy Decongestant, Aller-Chlor Decongestant, Sudogest Plus, Ryna Liquid, Genaphed Plus, Dayquil Allergy, Hayfebrol Liquid, Suphedrine Plus, Atrohist Pediatric Capsule, Histex, Triaminic Softchew Cold and Allergy, Chlor-Trimeton Allergy Decongestant SR, Tavist-DA, Biohist LA, Dynahist-ER Pediatric, Pediacare Cold and Allergy, CP-Tannic, Durafed, Histade, Duotan, Mintex, QDall, Suclor, Sudafed Sinus/Allergy, Re2+30, Sudal-12, Pediox Chewable, C-Phed Tannate, De-Congestine, Sudal-12 Chewable, Sudal-12 Tannate, SudaHist, Triaminic Softchews Allergy Nose & Congestion, Duratuss DA, Neutrahist Drops, AccuHist Drops, Sudogest Cold & Allergy, Dicel Chewables, PediaCare Cold/Allergy

Synonyms: Chlorpheniramine and pseudoephedrine, Chlorphen Mal, Pseudoeph HCl

What is Histex?

Vizimpro

Generic Name: dacomitinib

Brand name: Vizimpro

Synonyms: n.a.

What is Vizimpro?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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