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Hivid and Valcyte

Determining the interaction of Hivid and Valcyte and the possibility of their joint administration.

Check result:

Hivid <> Valcyte

Relevance: 25.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The coadministration of ganciclovir or its prodrug, valganciclovir, with zalcitabine may result in elevated plasma concentrations of ganciclovir. In 10 asymptomatic subjects with HIV and CMV coinfection, zalcitabine (0.75 mg orally every 8 hours) increased the peak plasma concentration and area under the concentration-time curve of ganciclovir (1000 mg orally every 8 hours) by an average of 22% and 18%, respectively, although only the former was statistically significant. The mechanism is unknown. Ganciclovir had minimal effect on the pharmacokinetics of zalcitabine. This interaction is unlikely to be of clinical significance.

References

Jung D, AbdelHameed MH, Teitelbaum P, Dorr A, Griffy K "The pharmacokinetics and safety profile of oral ganciclovir combined with zalcitabine or stavudine in asymptomatic HIV- and CMV-seropositive patients." J Clin Pharmacol 39 (1999): 505-12
"Product Information. Valcyte (valganciclovir)" Roche Laboratories, Nutley, NJ.

Hivid

Generic Name: zalcitabine

Brand name:

Synonyms: n.a.

What is Hivid?

Valcyte

Generic Name: valganciclovir

Brand name: Valcyte

Synonyms: n.a.

What is Valcyte?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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