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Hizentra and Soliris

Determining the interaction of Hizentra and Soliris and the possibility of their joint administration.

Check result:

Hizentra <> Soliris

Relevance: 07.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

According to the prescribing information for eculizumab, intravenous immunoglobulin (IVIg) treatment may interfere with the endosomal neonatal Fc receptor (FcRn) recycling mechanism of monoclonal antibodies such as eculizumab, which may lead to decreased serum concentrations of eculizumab. The clinical significance is unknown. Drug interaction studies have not been conducted with eculizumab in patients treated with IVIg.

References

"Product Information. Soliris (eculizumab)." Alexion Pharmaceuticals Inc, Cheshire, CT.

Hizentra

Generic Name: immune globulin subcutaneous

Brand name: Hizentra, Cutaquig, Cuvitru, Vivaglobin, Xembify

Synonyms: n.a.

What is Hizentra?

Soliris

Generic Name: eculizumab

Brand name: Soliris

Synonyms: n.a.

What is Soliris?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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