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HumaLog Mix 50/50 (Insulin Lispro Protamine and Insulin Lispro (Vials)) and Phentolamine Injection

Determining the interaction of HumaLog Mix 50/50 (Insulin Lispro Protamine and Insulin Lispro (Vials)) and Phentolamine Injection and the possibility of their joint administration.

Check result:

HumaLog Mix 50/50 (Insulin Lispro Protamine and Insulin Lispro (Vials)) <> Phentolamine Injection

Relevance: 17.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Phentolamine can increase the endogenous secretion of insulin in patients with type II diabetes mellitus. Theoretically, this effect could decrease insulin requirements. However, since phentolamine is usually administered only in single doses, the clinical importance is probably limited. Management consists of carefully monitoring blood glucose after the administration of phentolamine if the situation warrants.

References

Linde J, Deckert T "Increase of insulin concentration in maturity-onset diabetics by phentolamine (Regitine) infusion." Horm Metab Res 5 (1973): 391-5
Persson I, Larsen L "Serum insulin concentration after alpha-adrenergic blockade and secretin in diabetics." Acta Endocrinol (Copenh) 71 (1972): 331-7

HumaLog Mix 50/50 (Insulin Lispro Protamine and Insulin Lispro (Vials))

Generic Name: insulin lispro / insulin lispro protamine

Brand name: Humalog Mix 50/50, Humalog Mix 50/50 KwikPen, Humalog Mix 75/25, Humalog Mix 75/25 KwikPen, HumaLOG Mix 75/25 Pen, HumaLOG Mix 50/50 Pen

Synonyms: Insulin lispro and insulin lispro protamine, Insulin Lispro Protamine and Insulin Lispro

What is HumaLog Mix 50/50 (Insulin Lispro Protamine and Insulin Lispro (Vials))?

Phentolamine Injection

Generic Name: phentolamine

Brand name: OraVerse

Synonyms: Phentolamine

What is Phentolamine Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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