Humatin and Lanoxin (Digoxin Injection)
Determining the interaction of Humatin and Lanoxin (Digoxin Injection) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Oral neomycin has been shown to decrease the absorption of oral digoxin. The effects of oral paromomycin and kanamycin are not known. The proposed mechanism is a neomycin-induced malabsorption syndrome resulting in reduced absorption of drugs. This effect may be offset by a subsequent decrease in digoxin metabolism. During concomitant therapy with any of these antibiotics, digoxin serum concentrations and efficacy should be monitored. Patients should be advised to notify their physician if they experience a worsening of their heart symptoms.
- Lindenbaum J, Tse-Eng D, Butler VP, Rund DG "Urinary excretion of reduced metabolites of digoxin." Am J Med 71 (1981): 67-74
- Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
- Lindenbaum J, Maulitz RM, Butler VP "Inhibition of digoxin absorption by neomycin." Gastroenterology 71 (1976): 399-404
Generic Name: paromomycin
Brand name: Humatin, Paromycin
Synonyms: Humatin (Oral)
Generic Name: digoxin
Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin
Synonyms: Lanoxin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Humatin-Lanoxin (Digoxin Tablets)
- Humatin-Lanoxin Injection Pediatric
- Humatin-Lanoxin Intravenous
- Humatin-Lanoxin Pediatric
- Humatin-Lanoxin Pediatric Intravenous
- Humatin-Lanoxin Tablets
- Lanoxin (Digoxin Injection)-Humatrope
- Lanoxin (Digoxin Injection)-Humibid CS
- Lanoxin (Digoxin Injection)-Humira
- Lanoxin (Digoxin Injection)-Humira Pediatric Crohns Start
- Lanoxin (Digoxin Injection)-Humira Pen
- Lanoxin (Digoxin Injection)-Humira Pen-CD/UC/HS Starter