Humatrope and Yondelis

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Somatropin may reduce the blood levels of trabectedin, which may make the medication less effective in some patients. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of trabectedin, which is primarily metabolized by the isoenzyme. In 9 study patients with advanced malignancies, administration of a single 1.3 mg/m2 infusion of trabectedin on day 6 of treatment with rifampin (600 mg daily for 6 days), a potent CYP450 3A4 inducer, resulted in a 22% decrease in mean trabectedin peak plasma concentration (Cmax) and 31% decrease in mean systemic exposure (AUC) compared to infusion of trabectedin alone. Results from a population pharmacokinetic analysis (n = 831) indicated that the plasma clearance of trabectedin was 19% higher in patients who received concomitant dexamethasone, a moderate CYP450 3A4 inducer, compared to those who did not.

MANAGEMENT: The possibility of diminished therapeutic effects should be considered when trabectedin is prescribed with CYP450 3A4 inducers. Close clinical and laboratory monitoring is recommended whenever a CYP450 3A4 inducer is added to or withdrawn from trabectedin therapy, and the dosage adjusted if necessary.

Humatrope

Generic Name: somatropin

Brand name: Genotropin, Humatrope, Norditropin FlexPro Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive, Genotropin Miniquick, Norditropin Nordiflex Pen, Tev-Tropin, Nutropin, Norditropin, Nutropin AQ, Nutropin Depot, Norditropin Cartridge, Saizen Click-Easy, Omnitrope Pen 5 Cartridge, HumatroPen, Omnitrope Pen 10 Cartridge, Nutropin AQ Pen 20 Cartridge, Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 20, Saizen Kit

Synonyms: n.a.

What is Humatrope?

Yondelis

Generic Name: trabectedin

Brand name: Yondelis

Synonyms: n.a.

What is Yondelis?