Humulin R (Concentrated) U-500 and Ziana

• Generic Name: insulin regular
• Dosage Forms: injection, solution
• Other Brand Names: Humulin R, HumuLIN R KwikPen, Myxredlin, Novolin R

Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Concentrated (U-500) insulin is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours. U-500 insulin is five times more concentrated than regular U-100 insulin.

U-500 insulin is used to improve blood sugar control in adults and children with diabetes mellitus who have significant daily insulin needs (more than 200 units per day).

U-500 insulin may also be used for purposes not listed in this medication guide.

• Generic Name: clindamycin / tretinoin topical
• Dosage Forms: gel
• Other Brand Names: Veltin, Ziana

Ziana is a gel containing a combination of clindamycin and tretinoin. Clindamycin is an antibiotic. It fights bacteria in the body.

Tretinoin is a form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly.

Ziana is used to treat severe nodular acne in adults and children who are at least 12 years old.

Ziana may also be used for purposes other than those listed in this medication guide.