Hyaluronate sodium Injection and Tisagenlecleucel Intravenous

• Generic Name: sodium hyaluronate
• Dosage Forms: n.a.
• Other Brand Names: Durolane, Euflexxa, Gel-One, Gelsyn-3, Hyalgan, Supartz, Supartz FX, Visco-3, Trivisc, GenVisc 850, Monovisc, Orthovisc, Synvisc, Synvisc-One

Hyaluronate is similar to a substance that occurs naturally in joints and that helps joints work properly by acting like a lubricant and shock absorber. Hyaluronate sodium is injected directly into the knee to relieve pain caused by osteoarthritis.

Hyaluronate sodium is to be administered only by or under the immediate supervision of your doctor.

• Generic Name: tisagenlecleucel
• Dosage Forms: n.a.
• Other Brand Names: Kymriah

Tisagenlecleucel injection is used to treat B-cell acute lymphoblastic leukemia (ALL) that has come back a second or later time or after other medicines did not work well in patients up to 25 years of age. Leukemia is a type of cancer where the body makes abnormal white blood cells.

Tisagenlecleucel injection is also used to treat diffuse large B-cell lymphoma (DLBCL) that has come back a second or later time or after at least 2 other medicines did not work well. Lymphoma is a type of cancer where the body makes abnormal white blood cells.

Tisagenlecleucel injection is an antineoplastic (cancer) medicine that is made from your own white blood cells. These cells are reprogrammed to contain a chimeric antigen receptor (CAR) to identify the cancer cells from the normal cells and kill them. Before you begin treatment, talk to your doctor about the benefits of tisagenlecleucel as well as the possible risks of receiving it.

Tisagenlecleucel is available only under a restricted distribution program called Kymriah® REMS (Risk Evaluation and Mitigation Strategy) Program.