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Hycamtin and Ribociclib and Letrozole

Determining the interaction of Hycamtin and Ribociclib and Letrozole and the possibility of their joint administration.

Check result:

Hycamtin <> Ribociclib and Letrozole

Relevance: 27.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ribociclib may increase the blood levels and effects of topotecan. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with ribociclib may increase the plasma concentrations and pharmacologic effects of drugs that are substrates of breast cancer resistance protein (BCRP), organic cation transporter-2 (OCT-2), multidrug and toxin extrusion 1 (MATE1), and/or bile salt efflux pump (BSEP) transporters. The proposed mechanism, based on in vitro data, is decreased clearance due to ribociclib-mediated inhibition of these transport proteins at clinically relevant concentrations.

MANAGEMENT: Caution is advised if ribociclib is used concomitantly with drugs that are substrates of BCRP, OCT-2, MATE1, and/or BSEP transport proteins, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever ribociclib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Kisqali (ribociclib)." Novartis Pharmaceuticals, East Hanover, NJ.

Hycamtin

Generic Name: topotecan

Brand name: Hycamtin

Synonyms: Hycamtin (oral/injection)

What is Hycamtin?

Ribociclib and Letrozole

Generic Name: letrozole / ribociclib

Brand name: Kisqali Femara Co-Pack 200 mg-25 mg Dose, Kisqali Femara Co-Pack 400 mg-25 mg Dose, Kisqali Femara Co-Pack 600 mg-25 mg Dose

Synonyms: Letrozole and ribociclib

What is Ribociclib and Letrozole?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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