Hycamtin (Topotecan Capsules) and Varubi (Rolapitant Tablets)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Rolapitant may increase the blood levels and effects of topotecan, even after you have stopped taking rolapitant for a few days. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with rolapitant may increase the plasma concentrations of drugs that are substrates of the breast cancer resistance protein (BCRP) transporter. When a 500 mg dose of sulfasalazine, a BCRP substrate, was administered with a 180 mg dose of rolapitant on day 1 of a pharmacokinetic study, sulfasalazine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 140% and 130%, respectively. When sulfasalazine was administered on day 8 without rolapitant, Cmax and AUC increased by 17% and 32%, respectively. The duration of BCRP inhibition was not studied beyond 7 days.

MANAGEMENT: Caution is advised when rolapitant is prescribed with drugs that are BCRP substrates, particularly those with a narrow therapeutic range such as methotrexate, topotecan, and irinotecan. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever rolapitant is added to or withdrawn from therapy.

Hycamtin (Topotecan Capsules)

Generic Name: topotecan

Brand name: Hycamtin

Synonyms: Hycamtin (oral/injection), Hycamtin

What is Hycamtin (Topotecan Capsules)?

Varubi (Rolapitant Tablets)

Generic Name: rolapitant

Brand name: Varubi

Synonyms: Varubi

What is Varubi (Rolapitant Tablets)?