Hydralazine and Ibuprofen and Diphenhydramine
Determining the interaction of Hydralazine and Ibuprofen and Diphenhydramine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking hydrALAZINE, tell your doctor if you also use ibuprofen. This combination may cause dizziness, headaches, or blurred vision. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of hydralazine and dihydralazine. This interaction suggests that prostaglandins play a pivotal role in the vasodilatory effects of hydralazine. However, data have been conflicting.
MANAGEMENT: Recommended management consists of monitoring the antihypertensive effectiveness of hydralazine or dihydralazine during therapy, increasing the dosage as necessary, or decreasing or substituting another drug for the NSAID.
- Cinquegrani MP, Liang CS "Indomethacin attenuates the hypotensive action of hydralazine." Clin Pharmacol Ther 39 (1986): 564-70
Generic Name: hydralazine
Brand name: Apresoline
Synonyms: HydrALAZINE
Generic Name: diphenhydramine / ibuprofen
Brand name: Advil PM, Advil PM Liqui-Gels, Ibuprofen PM, Motrin PM
Synonyms: Diphenhydramine and ibuprofen
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydralazine-Ibuprofen and Famotidine
- Hydralazine-Ibuprofen and oxycodone
- Hydralazine-Ibuprofen and Phenylephrine
- Hydralazine-Ibuprofen and pseudoephedrine
- Hydralazine-Ibuprofen Capsules
- Hydralazine-Ibuprofen Chewable Tablets
- Ibuprofen and Diphenhydramine-Hydralazine and hydrochlorothiazide
- Ibuprofen and Diphenhydramine-Hydralazine and isosorbide dinitrate
- Ibuprofen and Diphenhydramine-Hydralazine Hydrochloride
- Ibuprofen and Diphenhydramine-Hydralazine Injection
- Ibuprofen and Diphenhydramine-Hydralazine Oral, Injection, Intravenous
- Ibuprofen and Diphenhydramine-Hydralazine Tablets