Hydralazine and isosorbide dinitrate and Indocin (Indomethacin Suppositories)
Determining the interaction of Hydralazine and isosorbide dinitrate and Indocin (Indomethacin Suppositories) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking hydrALAZINE, tell your doctor if you also use indomethacin. This combination may cause dizziness, headaches, or blurred vision. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nonsteroidal anti-inflammatory drugs (NSAIDs) may attenuate the antihypertensive effect of hydralazine and dihydralazine. This interaction suggests that prostaglandins play a pivotal role in the vasodilatory effects of hydralazine. However, data have been conflicting.
MANAGEMENT: Recommended management consists of monitoring the antihypertensive effectiveness of hydralazine or dihydralazine during therapy, increasing the dosage as necessary, or decreasing or substituting another drug for the NSAID.
- Cinquegrani MP, Liang CS "Indomethacin attenuates the hypotensive action of hydralazine." Clin Pharmacol Ther 39 (1986): 564-70
Generic Name: hydralazine / isosorbide dinitrate
Brand name: BiDil
Synonyms: Isosorbide Dinitrate and Hydralazine
Generic Name: indomethacin
Brand name: Indocin, Indocin SR, Tivorbex
Synonyms: Indocin, Indocin Suppository
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydralazine and isosorbide dinitrate-Indocin (Indomethacin Suspension)
- Hydralazine and isosorbide dinitrate-Indocin Injection
- Hydralazine and isosorbide dinitrate-Indocin Intravenous
- Hydralazine and isosorbide dinitrate-Indocin Rectal
- Hydralazine and isosorbide dinitrate-Indocin SR
- Hydralazine and isosorbide dinitrate-Indocin Suppository
- Indocin (Indomethacin Suppositories)-Hydralazine Hydrochloride
- Indocin (Indomethacin Suppositories)-Hydralazine Injection
- Indocin (Indomethacin Suppositories)-Hydralazine Oral, Injection, Intravenous
- Indocin (Indomethacin Suppositories)-Hydralazine Tablets
- Indocin (Indomethacin Suppositories)-Hydrea
- Indocin (Indomethacin Suppositories)-Hydrisalic Topical