Hydrochlorothiazide and amiloride and Leader Heartburn Relief
Determining the interaction of Hydrochlorothiazide and amiloride and Leader Heartburn Relief and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Amiloride may decrease cimetidine serum levels by an unknown mechanism. The clinical significance of this interaction is not known.
- Smith AJ, Smith RN "Kinetics and bioavailability of two formulations of amiloride in man." Br J Pharmacol 48 (1973): 646-9
- Somogyi AA, Hovens CM, Muirhead MR, Bochner F "Renal tubular secretion of amiloride and its inhibition by cimetidine in humans and in an animal model." Drug Metab Dispos 17 (1989): 190-6
Generic Name: amiloride / hydrochlorothiazide
Brand name: Moduretic 5-50
Synonyms: Amiloride and Hydrochlorothiazide
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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