Hydrochlorothiazide and amiloride and Quinidine Controlled-Release Tablets
Determining the interaction of Hydrochlorothiazide and amiloride and Quinidine Controlled-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using quiNIDine together with aMILoride. Taking these drugs together can affect the rhythm of your heart. Call your doctor if you have symptoms of irregular heartbeat, chest tightness, blurred vision, nausea, and seizures. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited data indicate that amiloride may significantly exaggerate QRS segment prolongation associated with quinidine. In vitro data suggest that the proarrhythmic effect of the combination may be associated with a synergistic increase in sodium channel blockage.
MANAGEMENT: Alternative diuretic therapy, such as a thiazide, is recommended. If amiloride and quinidine must be used together, frequent and careful monitoring of the QRS segment length is recommended.
- Wang L, Sheldon RS, Mitchell LB, et al "Amiloride quinidine interaction: adverse outcomes." Clin Pharmacol Ther 56 (1994): 659-67
Generic Name: amiloride / hydrochlorothiazide
Brand name: Moduretic 5-50
Synonyms: Amiloride and Hydrochlorothiazide
Generic Name: quinidine
Brand name: Quin-G, Cardioquin, Quinora, Quinidex Extentabs, Quinaglute Dura-Tabs, Quin-Release
Synonyms: Quinidine, QuiNIDine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrochlorothiazide and amiloride-Quinidine Extended Release Tablets
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- Hydrochlorothiazide and amiloride-Quinidine Injection
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- Hydrochlorothiazide and amiloride-Quinidine Sulfate
- Hydrochlorothiazide and amiloride-Quinidine Sulfate Tablets
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