Hydrochlorothiazide and amiloride and Zimamox
Determining the interaction of Hydrochlorothiazide and amiloride and Zimamox and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Amiloride may decrease the absorption and the bioavailability of amoxicillin. The efficacy of amoxicillin may be reduced. The mechanism appears to be an amiloride-induced reduction in the transport system needed for beta-lactam antibiotics. No specific action is needed if amiloride and amoxicillin are coadministered, but the patient should be monitored for reduced antibiotic efficacy.
- Westphal JF, Jehl F, Brogard JM, Carbon C "Amoxicillin intestinal absorption reduction by amiloride: possible role of the na+-h+ exchanger." Clin Pharmacol Ther 57 (1995): 257-64
Generic Name: amiloride / hydrochlorothiazide
Brand name: Moduretic 5-50
Synonyms: Amiloride and Hydrochlorothiazide
Generic Name: amoxicillin
Brand name: Amoxil, Moxatag, Trimox
Synonyms: Amoxicillin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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