Hydrochlorothiazide and irbesartan and Selzentry (Maraviroc Oral Solution)
Determining the interaction of Hydrochlorothiazide and irbesartan and Selzentry (Maraviroc Oral Solution) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Maraviroc and hydroCHLOROthiazide may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Maraviroc may potentiate the hypotensive effect of some medications. In clinical trials, symptomatic postural hypotension was observed more often with maraviroc than with placebo when administered to healthy volunteers at higher than recommended dosages. However, when given at the recommended dosage to HIV subjects, postural hypotension occurred at a rate similar to placebo (approximately 0.5%).
MANAGEMENT: Caution is advised when maraviroc is prescribed to patients on concomitant medications known to lower blood pressure. Close monitoring for development of hypotension is recommended. Ambulatory patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their doctor if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
- "Product Information. Selzentry (maraviroc)." Pfizer U.S. Pharmaceuticals Group, New York, NY.
Generic Name: hydrochlorothiazide / irbesartan
Brand name: Avalide
Synonyms: Irbesartan and Hydrochlorothiazide
Generic Name: maraviroc
Brand name: Selzentry
Synonyms: Selzentry
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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