Hydrochlorothiazide and losartan and Ketoconazole (Systemic)
Determining the interaction of Hydrochlorothiazide and losartan and Ketoconazole (Systemic) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:In vitro data suggests that potent inhibitors of CYP450 3A4 isoenzymes may decrease the formation of the active metabolite of losartan. The clinical significance of this interaction is unknown. The clinician should remain aware of this potential interaction and adjust dosages if needed. (Data have shown that eprosartan, a similar compound to losartan, is not affected by inhibition of this enzyme.)
- "Product Information. Cozaar (losartan)." Merck & Co, Inc, West Point, PA.
Generic Name: hydrochlorothiazide / losartan
Brand name: Hyzaar
Synonyms: Losartan and Hydrochlorothiazide
Generic Name: ketoconazole
Brand name: Nizoral
Synonyms: Ketoconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrochlorothiazide and losartan-Ketoconazole and Hydrocortisone
- Hydrochlorothiazide and losartan-Ketoconazole Tablets
- Hydrochlorothiazide and losartan-Ketoprofen
- Hydrochlorothiazide and losartan-Ketoprofen Capsules
- Hydrochlorothiazide and losartan-Ketoprofen Extended-Release Capsules
- Hydrochlorothiazide and losartan-Ketorolac
- Ketoconazole (Systemic)-Hydrochlorothiazide and methyldopa
- Ketoconazole (Systemic)-Hydrochlorothiazide and metoprolol
- Ketoconazole (Systemic)-Hydrochlorothiazide and moexipril
- Ketoconazole (Systemic)-Hydrochlorothiazide and olmesartan
- Ketoconazole (Systemic)-Hydrochlorothiazide and propranolol
- Ketoconazole (Systemic)-Hydrochlorothiazide and quinapril