Hydrochlorothiazide and losartan and Seebri Neohaler inhalation
Determining the interaction of Hydrochlorothiazide and losartan and Seebri Neohaler inhalation and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Anticholinergic agents may increase the absorption and oral bioavailability of thiazide diuretics. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents. In six healthy volunteers, pretreatment with propantheline prolonged the time to reach peak plasma concentration (Tmax) for hydrochlorothiazide from 2.4 to 4.8 hours and increased its total 48-hour urinary recovery by 36%. Similar results were reported for chlorothiazide in another study. The clinical significance of these changes is unknown.
- Osman MA, Welling PG "Influence of propantheline and metoclopramide on the bioavailability of chlorothiazide." Curr Ther Res Clin Exp 34 (1983): 404-8
- Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7
Generic Name: hydrochlorothiazide / losartan
Brand name: Hyzaar
Synonyms: Losartan and Hydrochlorothiazide
Generic Name: glycopyrrolate
Brand name: Lonhala Magnair Starter Kit, Seebri Neohaler, Cuvposa, GLYRX-PF, Robinul, Robinul Forte
Synonyms: Seebri Neohaler (inhalation), Seebri Neohaler
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrochlorothiazide and losartan-Segesterone Acetate and Ethinyl Estradiol
- Hydrochlorothiazide and losartan-Segesterone acetate and ethinyl estradiol Vaginal
- Hydrochlorothiazide and losartan-Segluromet
- Hydrochlorothiazide and losartan-Seizalam Injection
- Hydrochlorothiazide and losartan-Seldane
- Hydrochlorothiazide and losartan-Select-OB
- Seebri Neohaler inhalation-Hydrochlorothiazide and methyldopa
- Seebri Neohaler inhalation-Hydrochlorothiazide and metoprolol
- Seebri Neohaler inhalation-Hydrochlorothiazide and moexipril
- Seebri Neohaler inhalation-Hydrochlorothiazide and olmesartan
- Seebri Neohaler inhalation-Hydrochlorothiazide and propranolol
- Seebri Neohaler inhalation-Hydrochlorothiazide and quinapril