Hydrochlorothiazide and losartan and Symax Duotab
Determining the interaction of Hydrochlorothiazide and losartan and Symax Duotab and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Anticholinergic agents may increase the absorption and oral bioavailability of thiazide diuretics. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents. In six healthy volunteers, pretreatment with propantheline prolonged the time to reach peak plasma concentration (Tmax) for hydrochlorothiazide from 2.4 to 4.8 hours and increased its total 48-hour urinary recovery by 36%. Similar results were reported for chlorothiazide in another study. The clinical significance of these changes is unknown.
- Osman MA, Welling PG "Influence of propantheline and metoclopramide on the bioavailability of chlorothiazide." Curr Ther Res Clin Exp 34 (1983): 404-8
- Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7
Generic Name: hydrochlorothiazide / losartan
Brand name: Hyzaar
Synonyms: Losartan and Hydrochlorothiazide
Generic Name: hyoscyamine
Brand name: Symax Duotab, A-Spaz, Levsin/SL, Oscimin, Colidrops, Hyosyne, HyoMax, Levsin, Anaspaz, Ed Spaz, Levbid, NuLev, Symax SR, Cystospaz, Levsin SL, Cystospaz-M, Levsinex SR, Symax SL, A-Spas S/L, Donnamar, Hyosol, NuLev, Spasdel, IB-Stat, Hyospaz, Symax FasTab, HyoMax SL, HyoMax SR, HyoMax FT, HyoMax DT, Levsinex, Symax, Symax FasTabs
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrochlorothiazide and losartan-Symax FasTab
- Hydrochlorothiazide and losartan-Symax FasTabs
- Hydrochlorothiazide and losartan-Symax SL
- Hydrochlorothiazide and losartan-Symax-SR
- Hydrochlorothiazide and losartan-Symbicort
- Hydrochlorothiazide and losartan-Symbicort 100 Turbuhaler
- Symax Duotab-Hydrochlorothiazide and methyldopa
- Symax Duotab-Hydrochlorothiazide and metoprolol
- Symax Duotab-Hydrochlorothiazide and moexipril
- Symax Duotab-Hydrochlorothiazide and olmesartan
- Symax Duotab-Hydrochlorothiazide and propranolol
- Symax Duotab-Hydrochlorothiazide and quinapril