Hydrochlorothiazide and methyldopa and Nembutal Sodium injection
Determining the interaction of Hydrochlorothiazide and methyldopa and Nembutal Sodium injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Some barbiturates may increase the plasma clearance of methyldopa. Antihypertensive effectiveness may be decreased. Data are available for phenobarbital only and are conflicting. The clinical relevance of this interaction is minimal.
- Kristensen M, Jorgensen M, Hansen T "Plasma concentration of alfamethyldopa and its main metabolite, methyldopa-O-sulphate during long-term treatment with alfamethyldopa with special reference to possible interaction with other drugs given simultaneously." Clin Pharmacol Ther 14 (1973): 139-40
- Kaldor A, Juvancz P, Demeczky M, et al "Enhancement of methyldopa metabolism with barbiturate." Br Med J 3 (1971): 518-9
- Kristensen M, Jorgensen M, Hansen T "Barbiturates and methyldopa metabolism." Br Med J 1 (1973): 49
Generic Name: hydrochlorothiazide / methyldopa
Brand name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50
Synonyms: Methyldopa and Hydrochlorothiazide
Generic Name: pentobarbital
Brand name: Nembutal Sodium, Nembutal
Synonyms: Nembutal Sodium (injection)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrochlorothiazide and methyldopa-Neo DM
- Hydrochlorothiazide and methyldopa-Neo-Fradin
- Hydrochlorothiazide and methyldopa-Neo-Metric
- Hydrochlorothiazide and methyldopa-Neo-Poly-Bac
- Hydrochlorothiazide and methyldopa-Neo-Poly-Dex
- Hydrochlorothiazide and methyldopa-Neo-Poly-Dex Eye Drops
- Nembutal Sodium injection-Hydrochlorothiazide and metoprolol
- Nembutal Sodium injection-Hydrochlorothiazide and moexipril
- Nembutal Sodium injection-Hydrochlorothiazide and olmesartan
- Nembutal Sodium injection-Hydrochlorothiazide and propranolol
- Nembutal Sodium injection-Hydrochlorothiazide and quinapril
- Nembutal Sodium injection-Hydrochlorothiazide and spironolactone