Hydrochlorothiazide and methyldopa and Pentobarbital injection
Determining the interaction of Hydrochlorothiazide and methyldopa and Pentobarbital injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Some barbiturates may increase the plasma clearance of methyldopa. Antihypertensive effectiveness may be decreased. Data are available for phenobarbital only and are conflicting. The clinical relevance of this interaction is minimal.
- Kristensen M, Jorgensen M, Hansen T "Plasma concentration of alfamethyldopa and its main metabolite, methyldopa-O-sulphate during long-term treatment with alfamethyldopa with special reference to possible interaction with other drugs given simultaneously." Clin Pharmacol Ther 14 (1973): 139-40
- Kaldor A, Juvancz P, Demeczky M, et al "Enhancement of methyldopa metabolism with barbiturate." Br Med J 3 (1971): 518-9
- Kristensen M, Jorgensen M, Hansen T "Barbiturates and methyldopa metabolism." Br Med J 1 (1973): 49
Generic Name: hydrochlorothiazide / methyldopa
Brand name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50
Synonyms: Methyldopa and Hydrochlorothiazide
Generic Name: pentobarbital
Brand name: Nembutal Sodium, Nembutal
Synonyms: Pentobarbital (injection), PENTobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrochlorothiazide and methyldopa-Pentobarbital Sodium
- Hydrochlorothiazide and methyldopa-Pentobarbital Sodium Injection
- Hydrochlorothiazide and methyldopa-Pentopak
- Hydrochlorothiazide and methyldopa-Pentosan polysulfate sodium
- Hydrochlorothiazide and methyldopa-Pentostatin
- Hydrochlorothiazide and methyldopa-Pentostatin Intravenous
- Pentobarbital injection-Hydrochlorothiazide and metoprolol
- Pentobarbital injection-Hydrochlorothiazide and moexipril
- Pentobarbital injection-Hydrochlorothiazide and olmesartan
- Pentobarbital injection-Hydrochlorothiazide and propranolol
- Pentobarbital injection-Hydrochlorothiazide and quinapril
- Pentobarbital injection-Hydrochlorothiazide and spironolactone