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Hydrochlorothiazide and methyldopa and Phenylephrine (Systemic)

Determining the interaction of Hydrochlorothiazide and methyldopa and Phenylephrine (Systemic) and the possibility of their joint administration.

Check result:

Hydrochlorothiazide and methyldopa <> Phenylephrine (Systemic)

Relevance: 16.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using phenylephrine together with methyldopa may cause an increase in blood pressure. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or need your blood pressure checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that methyldopa and other sympatholytics may increase or prolong the pressor effect of sympathomimetics. Hypertension may result. Data exist for phenylpropanolamine and norepinephrine.

MANAGEMENT: If these drugs must be coadministered, blood pressure should be closely monitored. Discontinuation of the sympathomimetic may be necessary if hypertension develops.

References

McLaren EH "Severe hypertension produced by interaction of phenylpropanolamine with methyldopa and oxprenolol." Br Med J 2 (1976): 283-4
"Product Information. Allegra-D (fexofenadine-pseudoephedrine)." Chattem Consumer Products, Chattanooga, TN.

Hydrochlorothiazide and methyldopa

Generic Name: hydrochlorothiazide / methyldopa

Brand name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50

Synonyms: Methyldopa and Hydrochlorothiazide

What is Hydrochlorothiazide and methyldopa?

Phenylephrine (Systemic)

Generic Name: phenylephrine

Brand name: Nasop, Sudafed PE, Sudogest PE, Neo-Synephrine, Ah-Chew D, Despec-SF, Lusonal, Sudafed PE Quick Dissolve, Sudafed PE Extra Strength, Triaminic Thin Strips Nasal Congestion, Triaminic Toddler Congestion Thin Strips, Nasop12, Dimetapp Cold Drops, Triaminic Thin Strips Cold, Triaminic Thin Strips Infant Decongestant, Dimetapp Children's Cold & Allergy, Phenyl-T, PediaCare Children's Decongestant, Sudafed PE Children's Nasal Decongestant, Vazculep, Sudafed PE Congestion, Contac-D

Synonyms: Phenylephrine

What is Phenylephrine (Systemic)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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