Hydrochlorothiazide and methyldopa and Tegretol XR
Determining the interaction of Hydrochlorothiazide and methyldopa and Tegretol XR and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using carBAMazepine together with hydroCHLOROthiazide may increase the risk of hyponatremia, a condition associated with low levels of salt in the blood. Symptoms may include nausea, vomiting, lethargy, weakness, muscle cramps, twitching, confusion, seizures, and even death in severe cases. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Carbamazepine may cause clinically significant hyponatremia. Data show that the risk of hyponatremia may be additive when carbamazepine and hydrochlorothiazide are used concurrently. Carbamazepine and other diuretics may interact in a similar manner.
MANAGEMENT: Clinical monitoring of patient mental status and periodic measurement of serum sodium concentrations is recommended. Patients should be advised to notify their caregiver if they experience possible symptoms of hyponatremia such as nausea, vomiting, lethargy, weakness, muscle cramps, twitching, confusion, or seizures.
- Yassa R, Nastase C, Camille Y, Henderson M, Belzile L, Beland F "Carbamazepine, diuretics, and hyponatremia: a possible interaction." J Clin Psychiatry 48 (1987): 281-3
- "Product Information. Carbatrol (carbamazepine)." Athena Neurosciences Inc, South San Francisco, CA.
Generic Name: hydrochlorothiazide / methyldopa
Brand name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50
Synonyms: Methyldopa and Hydrochlorothiazide
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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