Hydrochlorothiazide and methyldopa and Trandate Injection
Determining the interaction of Hydrochlorothiazide and methyldopa and Trandate Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Ask your doctor before using labetalol together with methyldopa. This can cause lead to a serious increase in your blood pressure. Call your doctor if you experience nausea, vomiting, sweating, flushing, stiff neck, headache, or heart palpitations. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: The combination of nonselective beta-blockers and methyldopa may cause hypertensive crises. Death has been reported. Causality has not been clearly established, as other drugs were involved. The mechanism may be related to unopposed alpha effects. Phentolamine may be useful for treatment of this interaction.
MANAGEMENT: It may be best to avoid this combination. Patients' blood pressure should be monitored during concurrent therapy. Patients should be advised to seek medical help if they experience any early symptoms of a hypertensive crisis including nausea, vomiting, sweating, flushing, stiff neck, headache, or palpitations.
- McLaren EH "Severe hypertension produced by interaction of phenylpropanolamine with methyldopa and oxprenolol." Br Med J 2 (1976): 283-4
- Nies AS, Shand DG "Hypertensive response to propranolol in a patient treated with methyldopa: a proposed mechanism." Clin Pharmacol Ther 14 (1973): 823-6
Generic Name: hydrochlorothiazide / methyldopa
Brand name: Aldoril 15, Aldoril 25, Aldoril D30, Aldoril D50
Synonyms: Methyldopa and Hydrochlorothiazide
Generic Name: labetalol
Brand name: Trandate, Normodyne
Synonyms: Labetalol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrochlorothiazide and methyldopa-Trandate Intravenous
- Hydrochlorothiazide and methyldopa-Trandolapril
- Hydrochlorothiazide and methyldopa-Trandolapril and verapamil
- Hydrochlorothiazide and methyldopa-Tranexamic acid
- Hydrochlorothiazide and methyldopa-Tranexamic Acid Injection
- Hydrochlorothiazide and methyldopa-Tranexamic acid Intravenous
- Trandate Injection-Hydrochlorothiazide and metoprolol
- Trandate Injection-Hydrochlorothiazide and moexipril
- Trandate Injection-Hydrochlorothiazide and olmesartan
- Trandate Injection-Hydrochlorothiazide and propranolol
- Trandate Injection-Hydrochlorothiazide and quinapril
- Trandate Injection-Hydrochlorothiazide and spironolactone