Hydrochlorothiazide and olmesartan and Teriflunomide
Determining the interaction of Hydrochlorothiazide and olmesartan and Teriflunomide and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Teriflunomide may increase the blood levels and effects of olmesartan. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with teriflunomide may increase the plasma concentrations and the risk of adverse effects of drugs that are substrates of the organic anion transporting polypeptide (OATP) 1B1 and 1B3 and/or breast cancer resistance protein (BCRP) transporters. The proposed mechanism, based on in vivo data, is decreased clearance due to teriflunomide-mediated inhibition of OATP 1B1/1B3 or BCRP transport proteins.
MANAGEMENT: Caution is advised if teriflunomide is used concomitantly with drugs that are substrates of OATP 1B1/1B3 and/or BCRP. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever teriflunomide is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: hydrochlorothiazide / olmesartan
Brand name: Benicar HCT
Synonyms: Olmesartan and Hydrochlorothiazide
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrochlorothiazide and olmesartan-Teriparatide
- Hydrochlorothiazide and olmesartan-Teriparatide Subcutaneous
- Hydrochlorothiazide and olmesartan-Terocin
- Hydrochlorothiazide and olmesartan-Terocin (Lidocaine and Menthol Patch)
- Hydrochlorothiazide and olmesartan-Terocin (Methyl Salicylate, Menthol, Lidocaine, and Capsaicin)
- Hydrochlorothiazide and olmesartan-Terramycin
- Teriflunomide-Hydrochlorothiazide and propranolol
- Teriflunomide-Hydrochlorothiazide and quinapril
- Teriflunomide-Hydrochlorothiazide and spironolactone
- Teriflunomide-Hydrochlorothiazide and telmisartan
- Teriflunomide-Hydrochlorothiazide and triamterene
- Teriflunomide-Hydrochlorothiazide and valsartan