Hydrochlorothiazide and quinapril and Itraconazole
Determining the interaction of Hydrochlorothiazide and quinapril and Itraconazole and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Quinapril can bind to itraconazole in the gastrointestinal tract. This may inactivate itraconazole or interfere with its absorption into the bloodstream, possibly reducing its effectiveness. To avoid or minimize the interaction, you should try to take them at least 2 to 3 hours apart. Talk to your doctor if you have any questions or concerns, or if you have trouble separating the dosing times. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Administration of quinapril with some oral medications may significantly decrease their absorption and may result in subtherapeutic serum concentrations. The proposed mechanism is chelation of the drug by the magnesium hydroxide excipient in quinapril tablets.
MANAGEMENT: The manufacturer does not make a specific recommendation, but generally the administration of these drugs and magnesium-containing products should be separated by at least two to three hours.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Multum Information Services, Inc. Expert Review Panel"
Generic Name: hydrochlorothiazide / quinapril
Brand name: Accuretic, Quinaretic
Synonyms: Quinapril and Hydrochlorothiazide
Generic Name: itraconazole
Brand name: Onmel, Sporanox, Sporanox PulsePak, Tolsura
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrochlorothiazide and quinapril-Itraconazole Capsules (Sporanox)
- Hydrochlorothiazide and quinapril-Itraconazole Capsules (Tolsura)
- Hydrochlorothiazide and quinapril-Itraconazole Oral Solution
- Hydrochlorothiazide and quinapril-Itraconazole Tablets
- Hydrochlorothiazide and quinapril-Ivabradine
- Hydrochlorothiazide and quinapril-Ivabradine Hydrochloride
- Itraconazole-Hydrochlorothiazide and spironolactone
- Itraconazole-Hydrochlorothiazide and telmisartan
- Itraconazole-Hydrochlorothiazide and triamterene
- Itraconazole-Hydrochlorothiazide and valsartan
- Itraconazole-Hydrochlorothiazide Capsules
- Itraconazole-Hydrochlorothiazide Tablets