Hydrochlorothiazide and spironolactone and Obeticholic acid

• Generic Name: hydrochlorothiazide / spironolactone
• Dosage Forms: n.a.
• Other Brand Names: Aldactazide

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Hydrochlorothiazide and spironolactone is a combination medicine used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. This medication also treats high blood pressure (hypertension).

Do not use hydrochlorothiazide and spironolactone for any condition that has not been checked by your doctor.

Hydrochlorothiazide and spironolactone may also be used for purposes not listed in this medication guide.

• Generic Name: obeticholic acid
• Dosage Forms: n.a.
• Other Brand Names: Ocaliva

Primary biliary cholangitis (PBC) is a chronic liver disease that gradually destroys bile ducts in the liver. These ducts deliver bile to the small intestines, to help your body digest fats and nutrients. When PBC destroys these ducts, the bile stays in your liver and damages its cells. This can lead to cirrhosis (scarring of the liver) and liver failure. PBC is a progressive disease that may have no symptoms for many years. Treating PBC can help keep the liver functioning normally.

Obeticholic acid is used to treat PBC in adults and is sometimes used together with another drug called ursodeoxycholic acid (UDCA).

Obeticholic acid was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people with PBC responded to obeticholic acid, but further studies are needed.

Obeticholic acid may also be used for purposes not listed in this medication guide.