Hydrocortisone injection and Incivek

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Telaprevir may increase the blood levels of hydrocortisone. You may be more likely to experience side effects such as swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Other side effects that may occur include decreased ability to fight infections, increased risk of developing infections, and inadequate response to stress such as infection, surgery, trauma, or a severe asthma attack. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with telaprevir may increase the plasma concentrations of systemic corticosteroids. The mechanism involves telaprevir inhibition of CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of most steroids. No pharmacokinetic data are currently available, although telaprevir is a potent CYP450 3A4 inhibitor and may interact significantly.

MANAGEMENT: The use of systemic corticosteroids in combination with telaprevir is not recommended. Systemic corticosteroids should not be used to treat telaprevir-induced rash.

Hydrocortisone injection

Generic Name: hydrocortisone

Brand name: Cortef, Colocort, Cortenema, Cortifoam, Solu-Cortef

Synonyms: Hydrocortisone, Hydrocortisone (Systemic)

What is Hydrocortisone injection?

Incivek

Generic Name: telaprevir

Brand name: Incivek

Synonyms: n.a.

What is Incivek?