Hydrocortisone Injection Solution and Isoniazid Solution
Determining the interaction of Hydrocortisone Injection Solution and Isoniazid Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Plasma concentrations of isoniazid may be reduced during coadministration with corticosteroids. The mechanism of interaction has not been established, but may involve enhanced hepatic and/or renal elimination of isoniazid. In a study of 26 patients with tuberculosis given isoniazid 10 mg/kg/day, investigators reported a 23% reduction in plasma isoniazid concentrations for slow acetylators and a 38% reduction for rapid acetylators following the administration of a single 20 mg dose of prednisolone. The clinical significance of this potential interaction is unknown. Prednisolone did not appear to alter the clinical response to isoniazid treatment in the study. Nonetheless, it may be advisable to monitor patient response to isoniazid more closely during concomitant corticosteroid therapy and adjust the isoniazid dosage if necessary.
- Sarma G, Kailasam S, Nair NG, Narayana AS, Tripathy SP "Effect of prednisonlone and refampin on isoniazid metabolism in slow and rapid inactivators of isoniazid." Antimicrob Agents Chemother 18 (1980): 661-6
- Brodie MJ, Boobis AR, Hillyard CJ, Abeyasekera G, MacIntyre I, Park BK "Effect of isoniazid on vitamin D metabolism and hepatic monooxygenase activity." Clin Pharmacol Ther 30 (1981): 363-7
Generic Name: hydrocortisone
Brand name: Cortef, Colocort, Cortenema, Cortifoam, Solu-Cortef
Synonyms: Hydrocortisone, Hydrocortisone (Systemic)
Generic Name: isoniazid
Brand name: Nydrazid
Synonyms: Isoniazid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrocortisone Injection Solution-Isoniazid Syrup
- Hydrocortisone Injection Solution-Isoniazid Tablets
- Hydrocortisone Injection Solution-Isoniazid, pyrazinamide, and rifampin
- Hydrocortisone Injection Solution-Isoproterenol
- Hydrocortisone Injection Solution-Isoproterenol Hydrochloride
- Hydrocortisone Injection Solution-Isoproterenol Injection
- Isoniazid Solution-Hydrocortisone Iodoquinol Cream
- Isoniazid Solution-Hydrocortisone Lotion
- Isoniazid Solution-Hydrocortisone Lotion and Protective Emollient Cream
- Isoniazid Solution-Hydrocortisone Ointment
- Isoniazid Solution-Hydrocortisone probutate Topical application
- Isoniazid Solution-Hydrocortisone Rectal Cream