Hydrocortisone Rectal Suspension and Isavuconazonium Sulfate Injection
Determining the interaction of Hydrocortisone Rectal Suspension and Isavuconazonium Sulfate Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Isavuconazonium may increase the blood levels and effects of hydrocortisone. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with isavuconazonium sulfate (prodrug of isavuconazole) may increase the plasma concentrations of drugs that are substrates of CYP450 3A4 and/or P-glycoprotein (P-gp). The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity and/or P-gp-mediated efflux of these drugs by isavuconazole. In pharmacokinetic studies, isavuconazole increased the systemic exposure (AUC) of sensitive CYP450 3A4 substrates midazolam, sirolimus, and tacrolimus by approximately 2-fold, thus it can be considered a moderate inhibitor of the isoenzyme.
MANAGEMENT: Caution is advised when isavuconazonium sulfate is used concomitantly with drugs that are substrates of the CYP450 3A4 isoenzyme or the P-gp transport protein, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever isavuconazonium sulfate is added to or withdrawn from therapy.
- "Product Information. Cresemba (isavuconazonium)." Astellas Pharma US, Inc, Deerfield, IL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: hydrocortisone
Brand name: Cortef, Colocort, Cortenema, Cortifoam, Solu-Cortef
Synonyms: Hydrocortisone, Hydrocortisone (Systemic)
Generic Name: isavuconazonium
Brand name: Cresemba
Synonyms: Isavuconazonium, Isavuconazonium Sulfate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydrocortisone Rectal Suspension-Isentress
- Hydrocortisone Rectal Suspension-Isentress (Raltegravir Chewable Tablets)
- Hydrocortisone Rectal Suspension-Isentress (Raltegravir Powder for Oral Suspension)
- Hydrocortisone Rectal Suspension-Isentress (Raltegravir Tablets)
- Hydrocortisone Rectal Suspension-Isentress HD
- Hydrocortisone Rectal Suspension-Isibloom
- Isavuconazonium Sulfate Injection-Hydrocortisone Sodium Phosphate
- Isavuconazonium Sulfate Injection-Hydrocortisone Sodium Succinate
- Isavuconazonium Sulfate Injection-Hydrocortisone Suppository
- Isavuconazonium Sulfate Injection-Hydrocortisone Tablets
- Isavuconazonium Sulfate Injection-Hydrocortisone topical
- Isavuconazonium Sulfate Injection-Hydrocortisone Topical application