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Hydrocortisone (Systemic) and Zubsolv

Determining the interaction of Hydrocortisone (Systemic) and Zubsolv and the possibility of their joint administration.

Check result:

Hydrocortisone (Systemic) <> Zubsolv

Relevance: 03.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

A possible synergy was noted in a patient given a normal dose of naloxone followed by a 200 mg dose of hydrocortisone. In this case, naloxone was given for obtundation with minimal effect. The hydrocortisone was given in the same intravenous line approximately two minutes after the naloxone. Immediately after the hydrocortisone was given, the patient became alert. It is not known whether this effect was truly the result of a drug interaction.

References

Hensher R "A possible interaction between intravenous naloxone and hydrocortisone." Br J Clin Pract 37 (1983): 399-400

Hydrocortisone (Systemic)

Generic Name: hydrocortisone

Brand name: Cortef, Colocort, Cortenema, Cortifoam, Solu-Cortef

Synonyms: Hydrocortisone

What is Hydrocortisone (Systemic)?

Zubsolv

Generic Name: buprenorphine / naloxone

Brand name: Zubsolv, Bunavail, Suboxone

Synonyms: n.a.

What is Zubsolv?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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