Hydroxocobalamin injection and Nivolumab Intravenous

• Generic Name: hydroxocobalamin
• Dosage Forms: n.a.
• Other Brand Names: Cyanokit, Hydroxy-Cobal, Hydro-Cobex, Cobalin-H, Neo-Cytamen, Hydroxocobalamin

Hydroxocobalamin is a form of vitamin B-12. It is used as an antidote to cyanide poisoning. Hydroxocobalamin works by helping cells in the body convert cyanide to a form that can be removed from the body through urination.

Hydroxocobalamin is used in an emergency to treat cyanide poisoning. This type of poisoning can occur if you are exposed to smoke from a house or industrial fire, if you swallow or breathe in cyanide, or if you get cyanide on your skin.

Hydroxocobalamin may also be used for purposes not listed in this medication guide.

• Generic Name: nivolumab
• Dosage Forms: n.a.
• Other Brand Names: Opdivo

Nivolumab injection is used alone or together with other medicines (eg, ipilimumab) to treat melanoma (skin cancer) that has spread throughout the body (metastatic) or that cannot be removed by surgery. It is also used to help prevent melanoma from coming back after it and lymph nodes that contain cancer have been removed by surgery.

It is also used to treat non-small cell lung cancer that has spread throughout the body and after other cancer medicines have been tried but did not work well.

Nivolumab is also used to treat small cell lung cancer that has spread throughout the body and after at least two different kinds of cancer medicines have been tried but did not work well.

Nivolumab injection is used alone to treat kidney cancer that has spread throughout the body in patients who have received other medicines. It is also used together with ipilimumab to treat kidney cancer that has spread throughout the body in patients who have not received other medicines.

It is also used to treat classical Hodgkin lymphoma (white blood cell cancer) that has come back or spread after autologous hematopoietic stem cell transplantation (HSCT) and used brentuximab vedotin after stem cell transplant, or after you received at least 3 kinds of treatment including autologous HSCT.

Nivolumab is also used to treat squamous cell cancer of the head and neck (SCCHN) that has come back or spread throughout the body after receiving medicines containing platinum.

It is also used to treat patients with urothelial cancer (bladder cancer) that has spread or grown and have tried cancer medicines containing platinum but did not work well.

Nivolumab injection is also used alone or together with other medicines (eg, ipilimumab) to treat microsatellite instability high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer (cancer of the colon or rectum) that has spread or cannot be removed by surgery. It is given to patients who have received other cancer treatments (eg, fluoropyrimidine, oxaliplatin, irinotecan) that did not work well.

Nivolumab injection is also used to treat hepatocellular cancer (liver cancer) in patients who have received other medicines (eg, sorafenib).

Nivolumab is a monoclonal antibody that affects the immune system and helps control the growth of cancer cells.

Nivolumab is to be given only by or under the supervision of your doctor.