Hydroxyprogesterone Caproate and Robitussin Peak Cold Nasal Relief (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)
Determining the interaction of Hydroxyprogesterone Caproate and Robitussin Peak Cold Nasal Relief (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:HYDROXYprogesterone may reduce the blood levels and effects of acetaminophen. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with hydroxyprogesterone may decrease the plasma concentrations of drugs that are metabolized by CYP450 1A2, 2A6, and/or 2B6. An in vitro study using human liver microsomes and CYP isoform-selective substrates indicated that hydroxyprogesterone caproate can increase the metabolic rate of CYP450 1A2, 2A6, and 2B6 by approximately 80%, 150%, and 80%, respectively. The clinical significance has not been determined.
MANAGEMENT: Pharmacologic effects and/or serum concentrations of the coadministered drug should be monitored more closely whenever hydroxyprogesterone is added to or withdrawn from therapy, and the dosage adjusted if an interaction is suspected.
- "Product Information. Makena (hydroxyprogesterone)." Ther-Rx Corporation, Bridgeton, MO.
Generic Name: hydroxyprogesterone
Brand name: Makena, Makena Auto-Injector, Hylutin, Delta-Lutin, Duralutin, Hyprogesterone, Prodrox
Synonyms: Hydroxyprogesterone injection
Generic Name: acetaminophen / chlorpheniramine / phenylephrine
Brand name: Alka-Seltzer Plus Cold, Comtrex Severe Cold & Sinus, Contac Cold+Flu Maximum Strength, Dristan Cold Multi Symptom Formula, Robitussin Nighttime Nasal Relief, Tylenol Allergy Multi-Symptom, Tylenol Children's Plus Cold, Tylenol Sinus Congestion Nighttime, Contac Cold/Flu Day & Night, Coricidin D Cold/Flu/Sinus, Dristan Cold, Medicidin-D, Onset Forte, Robitussin Peak Cold Nasal Relief, Super Cold Tabs, Super Strength Sinadrin, Tylenol Sinus Congestion/Pain, Cold Relief Plus, EQL Effervescent Plus Cold, GNP Cold Relief Plus, QC Cold Relief Plus
Synonyms: Robitussin Nighttime Nasal Relief
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydroxyprogesterone Caproate-Robitussin Peak Cold Nighttime Cold + Flu
- Hydroxyprogesterone Caproate-Robitussin Pediatric Cough & Cold Long-Acting
- Hydroxyprogesterone Caproate-Robitussin Severe Congestion
- Hydroxyprogesterone Caproate-Rocaltrol (Calcitriol Capsules)
- Hydroxyprogesterone Caproate-Rocaltrol (Calcitriol Oral Solution)
- Hydroxyprogesterone Caproate-Rocephin
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- Robitussin Peak Cold Nasal Relief (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)-Hydroxyprogesterone Caproate Injection (Makena)
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- Robitussin Peak Cold Nasal Relief (Acetaminophen, Chlorpheniramine, and Phenylephrine Tablets)-Hydroxyprogesterone Intramuscular
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