Hydroxyprogesterone Caproate and Theraflu Max-D Severe Cold & Flu
Determining the interaction of Hydroxyprogesterone Caproate and Theraflu Max-D Severe Cold & Flu and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:HYDROXYprogesterone may reduce the blood levels and effects of acetaminophen. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with hydroxyprogesterone may decrease the plasma concentrations of drugs that are metabolized by CYP450 1A2, 2A6, and/or 2B6. An in vitro study using human liver microsomes and CYP isoform-selective substrates indicated that hydroxyprogesterone caproate can increase the metabolic rate of CYP450 1A2, 2A6, and 2B6 by approximately 80%, 150%, and 80%, respectively. The clinical significance has not been determined.
MANAGEMENT: Pharmacologic effects and/or serum concentrations of the coadministered drug should be monitored more closely whenever hydroxyprogesterone is added to or withdrawn from therapy, and the dosage adjusted if an interaction is suspected.
- "Product Information. Makena (hydroxyprogesterone)." Ther-Rx Corporation, Bridgeton, MO.
Generic Name: hydroxyprogesterone
Brand name: Makena, Makena Auto-Injector, Hylutin, Delta-Lutin, Duralutin, Hyprogesterone, Prodrox
Synonyms: Hydroxyprogesterone injection
Generic Name: acetaminophen / dextromethorphan / guaifenesin / pseudoephedrine
Brand name: Duraflu, Robitussin Cold Cough and Flu, Theraflu Max-D Severe Cold & Flu, Sudafed Cold and Cough Liquicaps, Theraflu Chest and Cough, Tylenol Cold Severe Congestion Non-Drowsy, Sudafed Sinus and Cold Liquicaps, Phlemgesic, Maxiflu DM, Flutabs, Tylenol Cold Severe Congestion
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hydroxyprogesterone Caproate-Theraflu Maximum Strength
- Hydroxyprogesterone Caproate-Theraflu Nighttime Severe Cold
- Hydroxyprogesterone Caproate-Theraflu Nighttime Severe Cough and Cold
- Hydroxyprogesterone Caproate-Theraflu PowerPods (Acetaminophen, Dextromethorphan, and Phenylephrine Pods)
- Hydroxyprogesterone Caproate-Theraflu PowerPods (Acetaminophen, Diphenhydramine, and Phenylephrine Pods)
- Hydroxyprogesterone Caproate-Theraflu Severe Cold & Congestion
- Theraflu Max-D Severe Cold & Flu-Hydroxyprogesterone Caproate Injection
- Theraflu Max-D Severe Cold & Flu-Hydroxyprogesterone Caproate Injection (Makena)
- Theraflu Max-D Severe Cold & Flu-Hydroxyprogesterone injection
- Theraflu Max-D Severe Cold & Flu-Hydroxyprogesterone Intramuscular
- Theraflu Max-D Severe Cold & Flu-Hydroxyquinoline vaginal
- Theraflu Max-D Severe Cold & Flu-Hydroxyurea