Hydroxyprogesterone Caproate Injection (Makena) and Theraflu Daytime Severe Cold

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

HYDROXYprogesterone may reduce the blood levels and effects of acetaminophen. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with hydroxyprogesterone may decrease the plasma concentrations of drugs that are metabolized by CYP450 1A2, 2A6, and/or 2B6. An in vitro study using human liver microsomes and CYP isoform-selective substrates indicated that hydroxyprogesterone caproate can increase the metabolic rate of CYP450 1A2, 2A6, and 2B6 by approximately 80%, 150%, and 80%, respectively. The clinical significance has not been determined.

MANAGEMENT: Pharmacologic effects and/or serum concentrations of the coadministered drug should be monitored more closely whenever hydroxyprogesterone is added to or withdrawn from therapy, and the dosage adjusted if an interaction is suspected.

Hydroxyprogesterone Caproate Injection (Makena)

Generic Name: hydroxyprogesterone

Brand name: Makena, Makena Auto-Injector, Hylutin, Delta-Lutin, Duralutin, Hyprogesterone, Prodrox

Synonyms: Hydroxyprogesterone injection, Hydroxyprogesterone Caproate

What is Hydroxyprogesterone Caproate Injection (Makena)?

Theraflu Daytime Severe Cold

Generic Name: acetaminophen / phenylephrine

Brand name: Alka-Seltzer Plus Cold and Sinus, Contac Cold+Flu Non-Drowsy, Excedrin Sinus Headache Caplet, Mapap Sinus Congestion and Pain, QlearQuil Daytime Sinus & Congestion, Robitussin Nasal Relief, Sinus Congestion and Pain Daytime Cool Ice, Sinus Pain & Pressure, Sudafed PE Sinus Headache, Theraflu Daytime Severe Cold, Tylenol Sinus Congestion and Pain, Congespirin Aspirin Free, Neo Citran Extra Strength Cold and Sinus, Mapap Sinus PE, Tylenol Sinus Congestion Daytime, Excedrin Sinus Headache, Non-Pseudo Sinus Pain & Pressure, Robitussin Peak Cold Nasal Relief, Sudafed PE Pressure Plus Pain, Contact Cold and Flu Day, Tylenol Sinus + Headache Day, Vicks Sinex Daytime, Mygrex, Acetaminophen Congestion and Pain, QlearQuil Sinus & Congestion, Vicks DayQuil Sinex

Synonyms: Acetaminophen and phenylephrine

What is Theraflu Daytime Severe Cold?