Hydroxyprogesterone Intramuscular and Methadone Injection Solution
Determining the interaction of Hydroxyprogesterone Intramuscular and Methadone Injection Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:HYDROXYprogesterone may reduce the blood levels and effects of methadone. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with hydroxyprogesterone may decrease the plasma concentrations of drugs that are metabolized by CYP450 1A2, 2A6, and/or 2B6. An in vitro study using human liver microsomes and CYP isoform-selective substrates indicated that hydroxyprogesterone caproate can increase the metabolic rate of CYP450 1A2, 2A6, and 2B6 by approximately 80%, 150%, and 80%, respectively. The clinical significance has not been determined.
MANAGEMENT: Pharmacologic effects and/or serum concentrations of the coadministered drug should be monitored more closely whenever hydroxyprogesterone is added to or withdrawn from therapy, and the dosage adjusted if an interaction is suspected.
- "Product Information. Makena (hydroxyprogesterone)." Ther-Rx Corporation, Bridgeton, MO.
Generic Name: hydroxyprogesterone
Brand name: Makena, Makena Auto-Injector, Hylutin, Delta-Lutin, Duralutin, Hyprogesterone, Prodrox
Synonyms: Hydroxyprogesterone (Intramuscular)
Generic Name: methadone
Brand name: Dolophine, Methadose, Methadose Sugar-Free, Diskets
Synonyms: Methadone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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