Hydroxyurea Capsules 500 mg and Videx Pediatric

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using didanosine together with hydroxyurea. Didanosine can cause severe or life-threatening effects on your liver or pancreas. Call your doctor at once if you have any of these symptoms while taking didanosine : severe pain in your upper stomach spreading to your back, fast heart rate, nausea and vomiting, diarrhea, loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). Didanosine may also cause lactic acidosis (the build up of lactic acid in the body). Lactic acidosis can start slowly and gradually get worse. Symptoms include unusual muscle pain and weakness, trouble breathing, fast or uneven heart rate, nausea, vomiting, stomach pain, and numbness or cold feeling in your arms or legs. Contact your doctor at once if you have any of these symptoms, even if they are only mild. Early signs of lactic acidosis generally get worse over time and this condition can be fatal. You may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Hydroxyurea may potentiate the risk of toxicities associated with the use of didanosine (ddI), a nucleoside reverse transcriptase inhibitor (NRTI). Specifically, concurrent use of hydroxyurea and ddI, with or without stavudine (d4T), has been associated with an increased risk of pancreatitis and peripheral neuropathy, the former of which may be fatal. Although rare, the syndrome of lactic acidosis and severe hepatomegaly with steatosis (with or without pancreatitis) may also occur more frequently with the combination than with ddI alone. Investigators theorize that hydroxyurea may enhance the potency of nucleoside analogues, particularly ddI, by preferentially depleting intracellular deoxyadenosine triphosphate and, to a lesser extent, other deoxynucleoside triphosphates. This action results in increased incorporation of the active metabolites of ddI and other NRTIs into DNA synthesis and disruption of the process.

MANAGEMENT: In general, antiretroviral regimens containing ddI and hydroxyurea should probably not be prescribed if other treatment options are available. Close observation for signs and symptoms of toxicity is recommended if these drugs must be used together, particularly in patients with advanced HIV disease and/or elderly patients. Both drugs should be suspended if pancreatitis is suspected, and ddI discontinued permanently if pancreatitis is confirmed. Prompt withdrawal of these drugs is also essential in patients who develop peripheral neuropathy to avoid irreversible damage. Therapy with ddI may be reinstituted following resolution of neuropathy symptoms, but reduced dosages are recommended. Likewise, treatment should be suspended in any patient who develops clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity, and permanent discontinuation considered if the syndrome is confirmed. Patients should be advised to seek medical attention promptly if symptoms of toxicity occur such as nausea, vomiting, abdominal pain, fatigue, unexplained weight loss, tachypnea, dyspnea, motor weakness, numbness, tingling, and pain in hands and feet.

Hydroxyurea Capsules 500 mg

Generic Name: hydroxyurea

Brand name: Droxia, Hydrea, Mylocel, Siklos

Synonyms: Hydroxyurea

What is Hydroxyurea Capsules 500 mg?

Videx Pediatric

Generic Name: didanosine

Brand name: Videx, Videx EC

Synonyms: Didanosine

What is Videx Pediatric?