Hyoscyamine, Atropine, Scopolamine, and Phenobarbital and Verapamil Immediate-Release Tablets
Determining the interaction of Hyoscyamine, Atropine, Scopolamine, and Phenobarbital and Verapamil Immediate-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking verapamil, tell your doctor if you also use PHENobarbital. You may need dose adjustments or special tests in order to safely take both medications together. You should monitor your blood pressure more closely for changes while taking verapamil whenever PHENobarbital is started or stopped. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Some barbiturates may significantly decrease serum verapamil concentrations and half-life, especially with oral dosage forms. The mechanism is induction of CYP450 3A4 first-pass metabolism of verapamil.
MANAGEMENT: Close observation for reduced verapamil effect is recommended if these drugs must be used together. Dose adjustments may be required. Patients should also be monitored for verapamil toxicity after the barbiturate is discontinued.
- Rutledge DR, Pieper JA, Mirvis DM "Effects of chronic phenobarbital on verapamil dispostion in humans." J Pharmacol Exp Ther 246 (1988): 7-13
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Belladonna alkaloids and phenobarbital
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Verapamil Injection
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Verapamil Intravenous
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Verapamil Long-Acting Capsules
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Verapamil Long-Acting Tablets
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Verapamil oral/injection
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Verapamil Sustained-Release Capsules
- Verapamil Immediate-Release Tablets-Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir
- Verapamil Immediate-Release Tablets-Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Tablets
- Verapamil Immediate-Release Tablets-Hyoscyamine, methenamine, methylene blue, and sodium biphosphate
- Verapamil Immediate-Release Tablets-Hyoscyamine, Methenamine, Methylene Blue, and Sodium Phosphate Monobasic
- Verapamil Immediate-Release Tablets-Hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium phosphate
- Verapamil Immediate-Release Tablets-Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate