Hyoscyamine, Atropine, Scopolamine, and Phenobarbital and Zarontin (Ethosuximide Capsules)
Determining the interaction of Hyoscyamine, Atropine, Scopolamine, and Phenobarbital and Zarontin (Ethosuximide Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using ethosuximide together with PHENobarbital may increase the effects of both medications. Contact your doctor if you experience confusion, slurred speech, stumbling or staggering walk, imbalance, nausea, vomiting, tremor, slow or shallow breathing, blurred vision, low blood pressure, extreme drowsiness, urinating less than usual or not at all, feeling light-headed, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The concomitant use of methsuximide and phenobarbital levels may result in increase serum levels of both drugs. The proposed mechanism is competition for the same metabolic pathway. Other succimides may also interact.
MANAGEMENT: If phenobarbital and a succinimide must be used together, monitoring of serum levels and observation for evidence of altered efficacy and safety is recommended. Dose adjustments may be necessary.
- Giaccone M, Bartoli A, Gatti G, Marchiselli R, Pisani F, Latella MA, Perucca E "Effect of enzyme inducing anticonvulsants on ethosuximide pharmacokinetics in epileptic patients." Br J Clin Pharmacol 41 (1996): 575-9
- Rambeck B "Pharmacological interactions of mesuximide with phenobarbital and phenytoin in hospitalized epileptic patients." Epilepsia 20 (1979): 147-56
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Belladonna alkaloids and phenobarbital
Generic Name: ethosuximide
Brand name: Zarontin
Synonyms: Zarontin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Zarontin (Ethosuximide Solution)
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Zarontin Capsules
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Zaroxolyn
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Zarxio
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Zatean-CH
- Hyoscyamine, Atropine, Scopolamine, and Phenobarbital-Zavara
- Zarontin (Ethosuximide Capsules)-Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Elixir
- Zarontin (Ethosuximide Capsules)-Hyoscyamine, Atropine, Scopolamine, and Phenobarbital Tablets
- Zarontin (Ethosuximide Capsules)-Hyoscyamine, methenamine, methylene blue, and sodium biphosphate
- Zarontin (Ethosuximide Capsules)-Hyoscyamine, Methenamine, Methylene Blue, and Sodium Phosphate Monobasic
- Zarontin (Ethosuximide Capsules)-Hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium phosphate
- Zarontin (Ethosuximide Capsules)-Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate