Ibrance and Zykadia

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 may increase the plasma concentrations of palbociclib, which is a substrate of the isoenzyme. In 12 healthy study subjects, administration of a single 125 mg dose of palbociclib with multiple 200 mg daily doses of itraconazole, a potent CYP450 3A4 inhibitor, resulted in 34% and 87% increases in palbociclib peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to palbociclib administered alone. The risk of adverse effects such as infections, neutropenia, leukopenia, anemia, thrombocytopenia, anorexia, nausea, vomiting, diarrhea, stomatitis, alopecia, asthenia, peripheral neuropathy, and epistaxis may be increased. MANAGEMENT: Concomitant use of palbociclib with potent CYP450 3A4 inhibitors should generally be avoided. Alternative agents with no or minimal CYP450 3A4 inhibitory potential are recommended whenever possible. If no alternatives exist, consider reducing the palbociclib dosage to 75 mg once daily. Following discontinuation of the potent CYP450 3A4 inhibitor, the palbociclib dosage should be returned (after 3 to 5 half-lives of the inhibitor) to that used prior to initiation of the inhibitor. References "Product Information. Ibrance (palbociclib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 may increase the plasma concentrations of palbociclib, which is a substrate of the isoenzyme. In 12 healthy study subjects, administration of a single 125 mg dose of palbociclib with multiple 200 mg daily doses of itraconazole, a potent CYP450 3A4 inhibitor, resulted in 34% and 87% increases in palbociclib peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to palbociclib administered alone. The risk of adverse effects such as infections, neutropenia, leukopenia, anemia, thrombocytopenia, anorexia, nausea, vomiting, diarrhea, stomatitis, alopecia, asthenia, peripheral neuropathy, and epistaxis may be increased.

MANAGEMENT: Concomitant use of palbociclib with potent CYP450 3A4 inhibitors should generally be avoided. Alternative agents with no or minimal CYP450 3A4 inhibitory potential are recommended whenever possible. If no alternatives exist, consider reducing the palbociclib dosage to 75 mg once daily. Following discontinuation of the potent CYP450 3A4 inhibitor, the palbociclib dosage should be returned (after 3 to 5 half-lives of the inhibitor) to that used prior to initiation of the inhibitor.

Ibrance

Generic Name: palbociclib

Brand name: Ibrance

Synonyms: n.a.

What is Ibrance?

Zykadia

Generic Name: ceritinib

Brand name: Zykadia

Synonyms: n.a.

What is Zykadia?