Ibu-200 and Omega-3-acid ethyl esters
Determining the interaction of Ibu-200 and Omega-3-acid ethyl esters and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using omega-3 polyunsaturated fatty acids together with ibuprofen. Fish oil and other products containing omega-3 fatty acids may rarely increase the risk of bleeding when combined with other medications that can also cause bleeding such as ibuprofen. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Omega-3 fatty acids (e.g., fish oil) may potentiate the pharmacologic effects of anticoagulants and other drugs that affect hemostasis such as platelet inhibitors, thrombin inhibitors, thrombolytic agents, dextran, and nonsteroidal anti-inflammatory drugs (NSAIDs). The exact mechanism of interaction is unknown. Omega-3 fatty acids may possess mild antiplatelet and hypocoagulant activities. In some studies, these substances have been shown to reduce thrombin generation and plasma levels of fibrinogen, prothrombin, and coagulation factors V, VII, and X. Prolongation of bleeding time has been demonstrated, although it did not exceed normal limits and did not produce clinically significant bleeding. The interaction was suspected in a case report of a 67-year-old woman treated with warfarin for 1.5 years who exhibited an increase in INR from 2.8 the previous month to 4.3 approximately one week after doubling her fish oil dosage from 1000 to 2000 mg/day. Prior to the increase, her INR had been stable and therapeutic for 5 months on warfarin 1.5 mg/day. The patient was advised to reduce her fish oil consumption to 1000 mg/day, while her warfarin dose was withheld for one day and then reduced to 1 mg alternating with 1.5 mg per day. Eight days later, her INR was subtherapeutic at 1.6, so the warfarin dosage was increased back to 1.5 mg/day. The patient's INR subsequently returned to therapeutic range.
MANAGEMENT: In general, patients should consult a healthcare provider before taking any herbal or nutritional supplements. Patients using omega-3 fatty acids in combination with anticoagulants or other drugs that affect hemostasis should be advised of the potential for increased risk of bleeding complications.
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- "Product Information. Vascepa (icosapent)." Amarin Pharmaceuticals Inc, Warren, NJ.
- Vanschoonbeek K, Feijge MA, Paquay J, et al "Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation." Arterioscler Thromb Vasc Biol 24 (2004): 1734-40
- "Product Information. Omacor (omega-3 polyunsaturated fatty acids)." Abbott Pharmaceutical, Abbott Park, IL.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Buckley MS, Goff AD, Knapp WE "Fish oil interaction with warfarin." Ann Pharmacother 38 (2004): 50-3
Generic Name: ibuprofen
Brand name: Advil, Advil Liqui-Gels, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Ibuprofen, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Caldolor, NeoProfen, Genpril, Ibu, Midol IB, Children's Motrin, Motrin Junior Strength
Synonyms: Ibu-200 (Oral)
Generic Name: omega-3 polyunsaturated fatty acids
Brand name: Divista, Fish Oil, Lovaza, MegaKrill, Nature's Bounty Red Krill Oil, Prenatal DHA, TheraTears Nutrition, Vascazen, Vayarin, Wellbaby DHA, Sea-Omega, Marine Lipid Concentrate, Super-EPA, MaxEPA, Proepa, Omega-500, EPA Fish Oil, Omega-3, Icar Prenatal Essential Omega-3, Omacor, Sea-Omega 30, Sea-Omega 70, Mi-Omega, Mi-Omega NF, Animi-3, MaxiVision Omega-3 Formula, MaxiTears Dry Eye Formula, Fish Oil Ultra, TherOmega, Animi-3 with Vitamin D, Flex Omega Benefits, Dry Eye Omega Benefits, Cardio Omega Benefits, Mom's Omega Advantage, Omega Essentials, Omega Essentials Basic, TherOmega Sport, Triple Strength Red Krill Oil, Salmon Oil, Dual Spectrum Omega-3, Disney Omega-3 Gummies, Epanova, Ovega-3 Vegetarian, Omega-3 D-3 Wellness Pack, Vayacog, Vayarin Plus, Triklo
Synonyms: Omega-3 polyunsaturated fatty acids, Omega-3 Fatty Acids
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ibu-200-Omega-3-carboxylic acids
- Ibu-200-Omegaven
- Ibu-200-Omeprazole
- Ibu-200-Omeprazole + SyrSpend SF Alka
- Ibu-200-Omeprazole and sodium bicarbonate
- Ibu-200-Omeprazole and Sodium Bicarbonate Capsule
- Omega-3-acid ethyl esters-Ibu-4
- Omega-3-acid ethyl esters-Ibu-6
- Omega-3-acid ethyl esters-Ibu-8
- Omega-3-acid ethyl esters-Ibu-Tab
- Omega-3-acid ethyl esters-Ibudone
- Omega-3-acid ethyl esters-Ibuprofen