Ibuprofen and Diphenhydramine and Liothyronine Sodium

• Generic Name: diphenhydramine / ibuprofen
• Dosage Forms: tablet
• Other Brand Names: Advil PM, Advil PM Liqui-Gels, Ibuprofen PM, Motrin PM

Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Antihistamines can cause drowsiness, which can aid in the treatment of occasional sleep problems (insomnia).

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Diphenhydramine and ibuprofen is a combination medicine used to treat occasional insomnia associated with minor aches and pains.

Diphenhydramine and ibuprofen is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Diphenhydramine and ibuprofen may also be used for purposes not listed in this medication guide.

• Generic Name: liothyronine
• Dosage Forms: n.a.
• Other Brand Names: Cytomel, Triostat

Used orally as replacement or supplemental therapy in congenital or acquired hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. Specific indications include primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) hypothyroidism.

Generally considered unsatisfactory for long-term use because of potential problems (i.e., wide swings in serum T3 concentrations, possibility of more pronounced adverse cardiovascular effects); however, may be useful when absorption of levothyroxine is questionable, when impairment of peripheral conversion of thyroxine to triiodothyronine is suspected, or in patients allergic to natural thyroid hormone. Levothyroxine is considered drug of choice for replacement therapy.

For treatment of congenital hypothyroidism (cretinism), levothyroxine is considered drug of choice.

Used IV for treatment of myxedema coma or precoma. Preferred by some clinicians over levothyroxine when a rapid effect or rapidly reversible effect is desired; however, levothyroxine generally is considered drug of choice for this use.

Treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto’s thyroiditis), and multinodular goiter.

Adjunct to radioiodine therapy in the management of thyroid cancer.

Used diagnostically in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy. Use with caution in patients in whom there is a strong suspicion of thyroid gland autonomy because exogenous hormone effects will be additive to endogenous source.