Ibuprofen and Phenylephrine and Valproate sodium Intravenous
Determining the interaction of Ibuprofen and Phenylephrine and Valproate sodium Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:High doses of ibuprofen (greater than 400 mg/day) may displace valproic acid from protein binding sites in vitro. This interaction may be more significant in uremic patients. Free valproic acid concentrations should be measured if toxicity is suspected.
- Dasgupta A, Volk A "Displacement of valproic acid and carbamazepine from protein binding in normal and uremic sera by tolmetin, ibuprofen, and naproxen: presence of inhibitor in uremic serum that blocks valproic acid-naproxen interactions." Ther Drug Monit 18 (1996): 284-7
Generic Name: ibuprofen / phenylephrine
Brand name: Advil Congestion Relief, Advil Sinus Congestion & Pain, Congestion Relief, Sudafed PE Head Congestion
Synonyms: n.a.
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Valproate sodium (Intravenous)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ibuprofen and Phenylephrine-Valproic acid
- Ibuprofen and Phenylephrine-Valproic Acid and Derivatives
- Ibuprofen and Phenylephrine-Valproic Acid Capsules
- Ibuprofen and Phenylephrine-Valproic Acid Liquid
- Ibuprofen and Phenylephrine-Valproic Acid Oral Solution
- Ibuprofen and Phenylephrine-Valproic Acid Syrup
- Valproate sodium Intravenous-Ibuprofen and pseudoephedrine
- Valproate sodium Intravenous-Ibuprofen Capsules
- Valproate sodium Intravenous-Ibuprofen Chewable Tablets
- Valproate sodium Intravenous-Ibuprofen Immediate Release Tablets
- Valproate sodium Intravenous-Ibuprofen injection
- Valproate sodium Intravenous-Ibuprofen Injection (PDA)