Ibuprofen and pseudoephedrine and Zantac (Ranitidine Injection)
Determining the interaction of Ibuprofen and pseudoephedrine and Zantac (Ranitidine Injection) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:H2 antagonists may alter the disposition of nonsteroidal anti-inflammatory drugs (NSAIDs), resulting in increased or decreased plasma concentrations. Data are varied, even for the same NSAID. The mechanism may be related to inhibition of metabolism, changes in gastric pH that decrease absorption, and/or reduced urinary elimination. Statistically significant changes have been small and of limited clinical significance. Clinical monitoring of patient response and tolerance is recommended.
- Scavone JM, Greenblatt DJ, Matlis R, Harmatz JS "Interaction of oxaprozin with acetaminophen, cimetidine, and ranitidine." Eur J Clin Pharmacol 31 (1986): 371-4
- Said SA, Foda AM "Influence of cimetidine on the pharmacokinetics of piroxicam in rat and man." Arzneimittelforschung 39 (1989): 790-2
- "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.
Generic Name: ibuprofen / pseudoephedrine
Brand name: Advil Cold & Sinus, Advil Cold and Sinus Liqui-Gel, Dimetapp Sinus, Dristan Sinus, Motrin IB Sinus, Sine-Aid IB, Dayquil Pressure and Pain Caplet, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Dimetapp Childrens Cold & Fever, Children's Ibuprofen Cold Relief
Synonyms: n.a.
Generic Name: ranitidine
Brand name: Zantac
Synonyms: Zantac
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ibuprofen and pseudoephedrine-Zantac (Ranitidine Syrup)
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- Ibuprofen and pseudoephedrine-Zantac Injection
- Ibuprofen and pseudoephedrine-Zapzyt Cleansing Topical
- Ibuprofen and pseudoephedrine-Zapzyt Topical
- Zantac (Ranitidine Injection)-Ibuprofen Capsules
- Zantac (Ranitidine Injection)-Ibuprofen Chewable Tablets
- Zantac (Ranitidine Injection)-Ibuprofen Immediate Release Tablets
- Zantac (Ranitidine Injection)-Ibuprofen injection
- Zantac (Ranitidine Injection)-Ibuprofen Injection (PDA)
- Zantac (Ranitidine Injection)-Ibuprofen Intravenous